Polydioxanone (PX) — Synthetic Monofilament Absorbable Suture
DemeDIOX is a POLYDIOXANONE monofilament synthetic absorbable suture prepared from the polyester, poly(p-dioxanone). Polydioxanone polymer has been found to be non-antigenic and elicits only a slight tissue reaction during absorption.
DemeTech's Polydioxanone is an absorbable, sterile, surgical suture ideal for internal tissues where a long-lasting, absorbable suture is preferable. As a synthetic material, it elicits less reactivity than natural absorbable sutures. DemeDIOX meets the requirements of the current edition of the United States Pharmacopeia.
Indicated for use in general soft tissue approximation, including use in pediatric cardiovascular tissue where growth is expected to occur, and ophthalmic surgery.
More DetailsUnderstanding how DemeDIOX Polydioxanone behaves once placed in the body
Two important characteristics describe the in vivo performance of absorbable sutures: tensile strength retention and absorption rate (loss of mass). DemeDIOX has been formulated to minimize the variability of these characteristics and to provide wound support through an extended healing period.
Data from implantation studies show that absorption is minimal until about the 90th post-implantation day, then essentially complete within 180–220 days — making DemeDIOX ideal where extended wound support is required.
Absorption is minimal until approximately the 90th post-implantation day. Essentially complete within 180–220 days — particularly useful where extended wound support up to six weeks is desirable.
Clinical trials show ~75–80% of initial strength at 2 weeks, ~65–70% at 4 weeks, and ~55–60% at 6 weeks — a well-characterised, gradually declining profile through the healing period.
Absorption occurs by hydrolysis with minimal tissue reactivity. As a synthetic material, Polydioxanone elicits less reactivity than natural absorbable sutures throughout the absorption process.
DemeTech's Polydioxanone sutures provide extended wound support with consistent, predictable absorption
DemeTech's Polydioxanone suture is an absorbable, sterile, surgical suture composed of the polyester, poly(p-dioxanone). It has been found to be nonantigenic and elicits only minimal tissue reactivity during the absorption process. Clinical trials have shown ~75–80% of initial strength at 2 weeks, ~65–70% at 4 weeks, and ~55–60% at 6 weeks. Complete absorption is within 180–220 days. DemeDIOX is available in violet and colorless and is ideal for internal tissues where a long-lasting, absorbable suture is preferable.
Prepared from the polyester poly(p-dioxanone), delivering smooth, consistent passage through tissue with a monofilament construction that minimises drag and tissue trauma.
Clinical trials confirm ~75–80% strength at 2 weeks, ~65–70% at 4 weeks, and ~55–60% at 6 weeks — providing reliable wound support through an extended healing period.
Polydioxanone polymer is non-antigenic and elicits only a slight tissue reaction during absorption — less reactivity than natural absorbable sutures, for a cleaner healing response.
Supplied in violet and colorless, giving surgeons the flexibility to select the most appropriate option for each clinical procedure.
Particularly suited to internal tissues where a long-lasting, absorbable suture is preferable, including pediatric cardiovascular tissue where growth is expected and ophthalmic surgery.
Absorption is minimal until ~day 90 post-implantation, then complete within 180–220 days. Especially useful where the combination of absorbable suture and extended wound support (up to six weeks) is desirable.
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