Aegle Alliance

Suture Material

What is Polyglactin 910?

DemeTECH's Polyglactin 910 suture is a synthetic absorbable, sterile, surgical suture composed of copolymers made from 90% glycolide and 10% L-lactide. Polyglactin 910 suture is available in violet or colorless from sizes USP 8-0 to USP 2.

Polyglactin 910 meets all requirements established by the United States Pharmacopeia (USP) and the European Pharmacopoeia (EP) for Synthetic Absorbable Surgical Sutures (except for an occasional oversize in some gauges).

Polyglactin 910 Suture is indicated for use in general soft tissue approximation and/or ligation, including use in ophthalmic surgery, but not for use in cardiovascular or neurological tissue.

More Details

90/10Glycolide / L-Lactide Copolymer

56–70Days — Complete Absorption

USP & EPPharmacopeia Compliant

Violet / ColorlessAvailable Colours

How It Works

Actions in Tissue

Understanding how Polyglactin 910 behaves once placed in the body

A slight tissue inflammation may occur when Polyglactin 910 Sutures are placed in tissue, which is characteristic of a foreign body response. This is followed by gradual encapsulation by connective tissue, after which absorption by hydrolysis begins.

Progressive loss of tensile strength and eventual absorption occurs as the polymer degrades. Absorption begins as a loss of tensile strength without appreciable loss of mass, continuing until the suture is completely absorbed between 56 and 70 days.

Foreign Body Response

A slight tissue inflammation occurs, characteristic of foreign body response, followed by gradual encapsulation of the suture by fibrous connective tissue.

Absorption by Hydrolysis

The polymer degrades to glycolic acid (or glycolic and lactic acids), which are subsequently absorbed and metabolized by the body — a clean, predictable breakdown pathway.

Tensile Strength Loss

Complete loss of original tensile strength occurs by 5 weeks post implantation. Absorption is essentially complete between 56 and 70 days after placement.

DemeTECH's Polyglactin 910 suture is a synthetic absorbable, sterile, surgical suture composed of copolymers made from 90% glycolide and 10% L-lactide. The chemical formula is (C₂H₂O₂)m(C₃H₄O₂)n. Clinical trials show that after two weeks, approximately 75% of initial strength remains; at four weeks, approximately 25% remains. Polyglactin 910 is nonantigenic, eliciting only mild tissue reactivity during the absorption process. Coated Polyglactin 910 sutures facilitate easy tissue passage, precise knot placement, smooth tie down, and a decreased tendency to irritate tissue.

Synthetic Copolymer Composition

Composed of 90% glycolide and 10% L-lactide copolymers (C₂H₂O₂)m(C₃H₄O₂)n, providing consistent and predictable material properties across every suture.

Proven Tensile Strength Retention

Clinical trials confirm ~75% of initial strength at 2 weeks, ~50% at 3 weeks post-op, and ~25% at 4 weeks — a well-characterised, predictable strength profile.

Nonantigenic & Mild Reactivity

DemeTECH's Polyglactin 910 is nonantigenic and elicits only mild tissue reactivity during the absorption process, supporting a cleaner healing environment.

Available in Violet & Colorless

Supplied in violet or colorless, from sizes USP 8-0 to USP 2, giving surgeons flexibility to select the most appropriate option for each procedure.

Coated for Easy Tissue Passage

Coated to create a smoother suture that passes through tissue readily, with a decreased tendency to irritate tissue and greater overall tensile strength.

Superior Knot Performance

Enables precise knot placement and smooth tie-down, giving surgeons confident, secure closures that hold reliably through the critical wound-healing period.

Usage

Indications

Do not resterilize. Discard open unused sutures. Store at room temperature. Avoid prolonged exposure to elevated temperatures.
As with any foreign body, prolonged contact with salt solutions such as those found in the urinary or biliary tracts may result in calculus formation.
Users should be familiar with surgical procedures and techniques involving absorbable sutures before employing Polyglactin 910 for wound closure, as risk of wound dehiscence may vary with the site of application and the suture material used.
Acceptable surgical practice should be followed with respect to drainage and closure of contaminated or infected wounds.
The use of this suture may be inappropriate in elderly, malnourished, or debilitated patients, or in patients suffering from conditions which may delay wound healing.
As this is an absorbable suture material, the use of supplemental non-absorbable sutures should be considered by the surgeon in the closure of sites which may undergo expansion, stretching, or distention.
Do not reuse. The reuse of single-use devices can cause cross contamination and affect device safety, performance, and effectiveness, exposing patients and staff to unnecessary risk.

Safety

Precautions

When handling Polyglactin 910 Sutures, handle the suture and needle with care, paying particular attention to the needle and avoiding damage from needle holders. The user should have sufficient knowledge and be familiar with absorbable sutures and their decreasing tensile strength before handling.
Under some circumstances, notably orthopedic procedures, immobilization by external support may be employed at the discretion of the surgeon.
Skin sutures which must remain in place longer than 7 days may cause localized irritation and should be snipped off or removed as indicated.
Care should be taken to avoid damage from handling. Avoid crushing or crimping damage due to application of surgical instruments such as forceps or needle holders.
Adequate knot security requires the accepted surgical technique of flat, square ties, with additional throws as warranted by surgical circumstance and the experience of the surgeon. The use of additional throws may be particularly appropriate when knotting monofilaments.
Polyglactin 910 is not suitable for elderly or debilitated patients or patients with retarded wound healing. Tissue with poor blood circulation may reject the suture material due to delayed absorption.

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